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Spicy Southern Cheesy Chicken Spaghetti Casserole (Family Favorite)

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Spicy Southern Cheesy Chicken Spaghetti Casserole—tender chicken, spaghetti, and cheese baked in a creamy, spicy sauce. Comforting and crowd-pleasing.

  • Total Time: 50 minutes
  • Yield: 8 servings 1x

Ingredients

Scale

12 oz spaghetti, cooked

3 cups cooked chicken, shredded

1 can cream of chicken soup

1 can cream of mushroom soup

1½ cups chicken broth

1 cup diced tomatoes with green chilies

1 cup shredded cheddar cheese

1 cup shredded Monterey Jack cheese

½ cup sour cream

2 tbsp hot sauce or Cajun seasoning

1 onion, diced

1 bell pepper, diced

2 garlic cloves, minced

1 tbsp olive oil

2 tbsp parsley

Instructions

1. Cook spaghetti until al dente; drain.

2. Sauté onion, pepper, and garlic in olive oil until softened.

3. Stir in soups, broth, tomatoes, sour cream, and hot sauce. Simmer 5 minutes.

4. Combine spaghetti, chicken, vegetables, and half of cheeses in bowl.

5. Pour sauce over mixture, toss, and transfer to greased baking dish.

6. Top with remaining cheese. Bake at 350°F for 25–30 minutes until bubbly.

7. Garnish with parsley and serve.

Notes

Make ahead: assemble and refrigerate up to 24 hours before baking.

For less spice, use mild tomatoes and less hot sauce.

Freeze unbaked casserole up to 2 months.

  • Author: Laura
  • Prep Time: 20 minutes
  • Cook Time: 30 minutes
  • Category: Dinner
  • Method: Baking
  • Cuisine: Southern-American

Nutrition

  • Serving Size: 1 square
  • Calories: 510
  • Sugar: 5 g
  • Sodium: 980 mg
  • Fat: 28 g
  • Saturated Fat: 14 g
  • Unsaturated Fat: 12 g
  • Trans Fat: 0 g
  • Carbohydrates: 38 g
  • Fiber: 3 g
  • Protein: 32 g
  • Cholesterol: 110 mg